FLCCC Alliance Protocols Quick Reference
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The following is for informational purposes only and is not medical advisement.
Pre-Exposure Prevention of COVID-19, Influenza and Respiratory Syncytial Virus (RSV)
2x daily Antiseptic antimicrobial mouthwash
5,000-10,000 IU daily Vitamin D: dosing varies; optimal target is greater than 50 ng/ml. Have blood levels checked. Best taken with food.
2x Daily 500 mg Vitamin C
20-50 mg/day Zinc
400-500 mg/day Resveratrol (Quercetin or Green Tea Extract orPterostilbene Combination Flavonoid) supplement. Assists in zinc absorption. Due to the possible drug interaction between quercetin and ivermectin, these drugs should not be taken simultaneously (i.e., should be staggered morning and night).
Elderberry syrup, supplements or gummies - follow manufacturer’s dosing recommendations
Take during periods of high transmission of COVID-19, influenza, and RSV. A triple combination containing elderberry, Vitamin C, and zinc may be a convenient approach. Patients with autoimmune disease should take for 2 weeks or less and monitor their symptoms closely.
See I-PREVENT: COVID, Flu and RSV Protection Protocol - FLCCC | Front Line COVID-19 Critical Care Alliance for detailed recommendations.
See also:
Treatment for Influenza and RSV
Nasal spray: 2-3 times a day with 1% povidone-iodine
Mouthwash: 2-3 times daily with
Antiseptic-antimicrobial mouthwash
Elderberry: 4 times daily, according to manufacturer’s dosing guidelines
Vitamin C: 500-1000 mg, 4 times daily
Zinc: 50-90 mg daily
N-acetylcysteine (NAC): 600-1200 mg orally, 2 times daily
Sunlight and photobiomodulation (PBM): 30 minutes daily
PBM is also known as low-level light therapy, red light therapy, and near-infrared light therapy.
Melatonin: 5-10 mg nightly
Slow- or extended-release preparations are preferred.
Nitazoxanide: 500 mg, 2 times daily
Nitazoxanide (NTZ), an oral antiparasitic drug, has activity against many protozoa and helminths and – like ivermectin – has been shown to have antiviral, anti-inflammatory, and immune-modulatory effects and broad spectrum antiviral activity that includes influenza virus, RSV, and SARS-CoV-2.
Ivermectin: 0.4 mg/kg for 5 days.
In-vitro (test tube) studies suggest that ivermectin has broad antiviral activity against RNA viruses including influenza. However, there is no (published) clinical data on the use of ivermectin in the treatment of influenza. Therefore, we recommend ivermectin as part of a multi-drug regimen when nitazoxanide is not available. Ivermectin is best taken with a meal. This drug should be avoided in pregnancy and in patients taking calcineurin inhibitors (cyclosporine and Prograf).
See I-CARE: RSV and Flu Treatment - FLCCC | Front Line COVID-19 Critical Care Alliance for detailed recommendations.
Guide to Early Treatment of COVID-19
First Line Therapies:
Ivermectin: 0.4 to 0.6 mg/kg – one dose daily for at least 5 days or until symptoms resolve.
Hydroxychloroquine (HCQ): 200 mg twice a day for 5 to 10 days.
Best taken with zinc. HCQ may be taken in place of, or together with, ivermectin.
Mouthwash antiseptic-antimicrobial: 3 times a day.
Nasal spray with 1% povidone-iodine: 2-3 times a day.
Quercetin (or a mixed flavonoid supplement): 250-500 mg twice a day.
Due to a possible interaction between quercetin and ivermectin, these drugs should not be taken simultaneously (i.e., should be staggered at different times of day.)
Nigella sativa: If using seeds, take 80 mg/kg once a day (or 400 to 500 mg of encapsulated oil twice a day).
Honey: 1 g/kg one to two times a day.
Melatonin: 5-10 mg before bedtime (causes drowsiness).
Slow- or extended-release formulations preferred.
Curcumin (turmeric): 500 mg twice a day.
Zinc: 75-100 mg daily.
Take with HCQ
Aspirin: 325 mg daily (unless contraindicated).
Kefir and/or Bifidobacterium Probiotics.
NOTE: Depending on the brand, these products can be very high in sugar, which promotes inflammation. Look for brands without added sugar or fruit jellies and choose products with more than one strain of lactobacillus and bifidobacteria.
Vitamin C: 500-1000 mg twice a day.
Home pulse oximeter
Take multiple readings over the course of the day and regard any downward trend as ominous. Baseline or ambulatory desaturation under 94% should prompt consultation with primary or telehealth provider, or evaluation in an emergency room.
Second Line Therapies
Nitazoxanide (NTZ): 500 mg twice a day for 5 days.
Vitamin D3
B complex vitamins
Fluvoxamine: 25-50 mg twice a day.
N-acetyl cysteine (NAC): 600-1200 mg orally twice a day.
Omega-3 fatty acids: 4 g daily.
Treatment of BA.4/BA.5/BQ.1.1 and XBB1 Variants
The following protocol should be used where BA.4/BA.5/BQ.1.1 and XBB1 are the predominant circulating strains.
Hydroxychloroquine (HCQ): 200 mg twice a day or 400 mg daily for 5 days
AND
Ivermectin: 0.4-0.6 mg/kg once daily for 5 days taken with a fatty meal
OR
Alternative to ivermectin: Nitazoxanide (500 mg three times a day for 5 days taken with a fatty meal).
Zinc: 75-100 mg daily for 5 days
Antiseptci/antimicrobial Mouthwash: 3 times a day.
Nasal spray with 1% povidone-iodine, Carrageenan, Nitric Oxide, or nasal irrigations with saline or neutral electrolyzed water: 2-3 times daily
Quercetin: 250-500 mg twice daily
Melatonin: 5-10 mg at night, slow-release formulation preferred
Nigella sativa: If using seeds, take 80 mg/kg once a day (or 400 to 500 mg of encapsulated oil twice a day taken with honey (1 g/kg one to two times a day).
Aspirin: 325 mg daily unless contraindicated
Home pulse oximetry
High-risk patients (aged over 60, comorbidities, poorly ambulatory), delayed treatment, high D-dimer, recently vaccinated, or severe symptoms, should add:
Apixaban: 5 mg daily for 15 days
OR
Spironolactone: 200 mg once daily for 7 days
avoid in patients with impaired renal function
If symptoms have not markedly improved by day 3 of treatment, the following medications should be started.
NOTE: physicians should provide prescriptions for these medications at first visit.
Prednisolone: 60 mg daily for 5 days
Oral antibiotic:
Doxycycline (100 mg twice daily for 5 days)
Doxycycline may act synergistically with ivermectin and may be the antibiotic of first choice
OR Azithromycin/Z-pack (500 mg day 1, then 250 mg daily for 4 days)
OR Amoxicillin/Clavulanate (Augmentin) (500 mg/125 mg tablet twice daily for 7 days)
See I-CARE: Early COVID Treatment for detailed recommendations.
Always consult with a qualified medical and/or nutritional professional well versed in this subject. Maintain regular checkups. Never attempt to self-diagnose.
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